The Association of the Temperature-Sensitive Phenotype with Viral Attenuation in Animals and Humans: Implications for the Development and Use of Live Virus Vaccines
Identifieur interne : 002890 ( Main/Exploration ); précédent : 002889; suivant : 002891The Association of the Temperature-Sensitive Phenotype with Viral Attenuation in Animals and Humans: Implications for the Development and Use of Live Virus Vaccines
Auteurs : Douglas D. Richman [États-Unis] ; Brian R. Murphy [États-Unis]Source :
- Reviews of Infectious Diseases [ 1058-4838 ] ; 1979.
Abstract
Viruses that possess temperature-sensiuve mutations are consistently attenuated in vivo compared with the wild-type parental strains. Such temperature-sensitive (ts) mutants are currently used in several live attenuated virus vaccines and have been proposed for use against several additional viral diseases, including influenza. This paper reviews the following: (1) the evidence that the ts mutation itself is responsible for attenuation; (2) experimental infection of animals and humans with ts mutant viruses; (3) the experience of humans with naturally occurring ts mutants; and (4) the rationale for the use of ts mutants in live virus vaccines. In addition, the potential of ts mutants to produce altered patterns of disease is considered. After the known and potential benefits and possible risks involved in the use of is mutant viruses are weighed, the continuing use and development of vaccines using live attenuated ts virus seems warranted.
Url:
DOI: 10.1093/clinids/1.3.413
Affiliations:
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Richman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Veterans Administration Medical Center and the Departments of Pathology and Medicine, University of California, San Diego, California, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Douglas D. Richman, Veterans Administration Hospital (111F), 3350 La Jolla Village Drive, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Veterans Administration Medical Center and the Departments of Pathology and Medicine, University of California, San Diego, California, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Reviews of Infectious Diseases</title><title level="j" type="abbrev">Reviews of Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1979-05">1979</date><biblScope unit="vol">1</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="413">413</biblScope><biblScope unit="page" to="433">433</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Viruses that possess temperature-sensiuve mutations are consistently attenuated in vivo compared with the wild-type parental strains. Such temperature-sensitive (ts) mutants are currently used in several live attenuated virus vaccines and have been proposed for use against several additional viral diseases, including influenza. This paper reviews the following: (1) the evidence that the ts mutation itself is responsible for attenuation; (2) experimental infection of animals and humans with ts mutant viruses; (3) the experience of humans with naturally occurring ts mutants; and (4) the rationale for the use of ts mutants in live virus vaccines. In addition, the potential of ts mutants to produce altered patterns of disease is considered. After the known and potential benefits and possible risks involved in the use of is mutant viruses are weighed, the continuing use and development of vaccines using live attenuated ts virus seems warranted.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Richman, Douglas D" sort="Richman, Douglas D" uniqKey="Richman D" first="Douglas D." last="Richman">Douglas D. Richman</name></region><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Richman, Douglas D" sort="Richman, Douglas D" uniqKey="Richman D" first="Douglas D." last="Richman">Douglas D. Richman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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